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Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

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 Astrochik    43




Prolonged fasting downregulates a IGF-1/PKA pathway in stem cells

Prolong fasting protects hematopoietic cells from chemotoxicity

Prolonged fasting cycles promote HSC self-renewal to reverse immunosuppression

Inhibition of IGF-1 or PKA signaling mimics the effects of prolonged fasting



Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal transduction changes in long-term hematopoietic stem cells (LT-HSCs) and niche cells that promote stress resistance, self-renewal, and lineage-balanced regeneration. Multiple cycles of fasting abated the immunosuppression and mortality caused by chemotherapy and reversed age-dependent myeloid-bias in mice, in agreement with preliminary data on the protection of lymphocytes from chemotoxicity in fasting patients. The proregenerative effects of fasting on stem cells were recapitulated by deficiencies in either IGF-1 or PKA and blunted by exogenous IGF-1. These findings link the reduced levels of IGF-1 caused by fasting to PKA signaling and establish their crucial role in regulating hematopoietic stem cell protection, self-renewal, and regeneration.

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​To complement this fast which is usually 3 days if we are talking about the same thing,
afterwards you should go on a 70-75% saturated fat, moderate protein, and very low
carb diet. This is the diet that gets the best results, and many people will not believe it
because of all the bullshit fed them their entire lives.

A high fat diet brings up your good cholesterol, lowers the bad cholesterol, and lowers
your triglycerides. It's actually the opposite of what you've been told. Your cells need
cholesterol and fat to rebuild, and your brain is mostly water and fat and cholesterol.

You should not let this miracle discovery get away from you. You should do some
serious research on it. You'll be very surprised what you'll discover if you take the
time, and have an open mind.

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